Molecular and cellular cardiology focuses on understanding the fundamental mechanisms that govern heart function at the smallest biological levels. This field explores how genes, proteins, and signaling pathways regulate the growth, development, and survival of cardiac cells, including cardiomyocytes, fibroblasts, and endothelial cells. Advances in molecular biology, genomics, and proteomics have enabled researchers to identify key molecular targets involved in cardiac hypertrophy, apoptosis, inflammation, and myocardial remodeling. These discoveries are crucial for unraveling the causes of heart diseases such as cardiomyopathies, arrhythmias, and heart failure, offering new perspectives for prevention and treatment.
Recent progress in stem cell biology, gene editing technologies like CRISPR-Cas9, and regenerative medicine has opened the possibility of repairing damaged heart tissue at the cellular level. Studies on molecular signaling pathways, mitochondrial dynamics, and calcium handling have improved our understanding of energy metabolism and contractility in healthy and diseased hearts. Additionally, the integration of molecular data with advanced imaging and computational modeling has allowed for a more precise interpretation of cardiac pathophysiology. By linking cellular mechanisms to whole-heart function, molecular and cellular cardiology continues to drive the development of novel therapeutic strategies, leading toward more effective and personalized approaches in cardiovascular medicine.