Speakers - 2026

Title: Advancing the Care of Heart Failure and T2DM

Abstract

Heart failure is a clinical syndrome caused by a structural and/or functional cardiac abnormality, resulting in a reduced cardiac output and/or elevated intracardiac pressures at rest or during stress.1 Heart failure poses a significant global disease burden, more than 60 million patients worldwide have heart failure. Approximately 50% of patients diagnosed with heart failure will die within 5 years2-3 . There are 537 million patient with diabetes mellitus all over the world .4 People with diabetes have a 2- to 5-fold higher risk of developing HF 5 , On the other hand more than 30% of patients with heart failure also have diabetes. 6 Patients with heart failure and diabetes have a worse prognosis than those without diabetes 6 . Accord and advance trials showed that Intensive glycaemic control has not been shown to significantly impact the risk of HF. 7Specific glucoselowering medications have not been shown to improve heart failure outcomes, and some may actually have deleterious effects.8-10 Glucose in the blood is freely filtered by the glomerulus and reabsorbed again through proximal convoluted tube., The transport of glucose from the tubule into the tubular epithelial cells is accomplished by sodium- glucose cotransporters (SGLTs) family, SGLT2 in the proximal segment of the renal proximal tubule is responsible for 90% of glucose reabsorption and SGLT1 in the distal segment of the renal proximal tubule responsible for reabsorbtion the rest 10% of glucose.